N-4674 is a natural effective cutting agent, an endurance and performance enhancer, it acts as an AMPK (5’ adenosine monophosphate-activated protein kinase) activator. N-4674 is more effective then the product AICAR*.
N-4674 contains a citrus ketone called nootkatone as its phytochemical constitute. Nootkatone is the primary aromatic compound in grapefruit, yet is only found in the low yields of 0.0025% in the fruit. In 2015, a controlled study was done using very large amounts of freshly squeezed grapefruit juice vs prescription fat loss drugs. The grapefruit juice was 300% more effective at burning fat without all the side-effects of synthetic stimulants. But why? Later on in 2015 a study was done on potential anti-cancer chemicals, nootkatone was part of this study. It was found nootkatone was a potent AMPK activator, involved in energy and ATP synthesis, having anti-tumour properties by directly killing lipid (fat) cells.
What N-4674 Does:
It is a potent AMPK activator (same pathway as AICAR)
Stimulates fatty acid oxidation
Activates energy by binding to AMP and ADP (similar mechanism of action as ATP)
Increases muscle cellular energy and endurance
Increases fat loss and regulates cholesterol synthesis
Induces glucose uptake
N-4674 is more effective then the AICAR*
18.95mg/mL | 3.2mL/day | 60.64mg/day
1.6mL twice daily | one month supply
N-4674 contains nootkatone (4-α,5-dimethyl-1,2,3,4,4α,5,6,7-octahydro-7-keto-3-isopropenylnaphthalene), in a proprietary SMEDDS blend.
The active compound is isolated from grapefruit.
Nootkatone has high lipophilicity and requires SMEDDS to be effective. Our proprietary SMEDDS blend is infused with capric acid, a natural PPAR-γ agonist.
To activate SMEDDS mix the recommended dose by stirring vigorously, shaking, or blending in water, milk, or juice.
Adenosine Stimulation Of N-4674 vs AICAR*
N-4674 (Nootkatone) 
Inhibits NF-κB (a factor involved in cell survival)
AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) 
Binds to AMPK-γ subunit
Stimulates mitochondrional apoptosis pathway
Inhibition of mTOR pathway (regulates cell growth)
N-4674 directly activates adenosine whilst AICAR only mimics adenosine. This makes N-4754 superior to AICAR.
Arkwright, R. T., Deshmukh, R., Adapa, N., Stevens, R., Zonder, E., Zhang, Z., Farshi, P., Ahmed, R. S. I., El-Banna, H. A., Chan, T. H. & Dou, Q. P. 2015. Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics. Anticancer Agents In Medicinal Chemistry, 15(5), 657-671. PMID: 25511514
Winder, W. W. & Hardie, D. G. 1999. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. American Journal Of Physiology, 277(1), pp. E1-E10. DOI: 10.1152/ajpendo.1999.277.1.E1
Holmes, B. F., Kurth-Kraczek, E. J. & Winder, W. W. 1999.Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. Journal of Applied Physiology, 87(5), pp. 1990-2010. DOI: 10.1152/jappl.1918.104.22.1680
Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W. & Goodyear, L. J. 1998. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes, 47(8), 1369-1373. DOI: 10.2337/diabetes.47.8.1369
Ojuka, E. O., Jones, T. E., Nolte, L. A., Chen, M., Wamhoff, B. R., Sturek, M. & Holloszy, J. O. 2002. Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+. American Journal Of Physiology, 282(5), pp. E1008-E1013. DOI: 10.1152/ajpendo.00512.2001
Farouk, H., Mahmoud, S. S., El-Sayeh, B. A. & Sharaf, O. A. 2015. Effect of grapefruit juice and sibutramine on body weight loss in obese rats. African Journal of Pharmacy and Pharmacology, 9(8), pp. 265-273. DOI: 10.5897/AJPP2014. 4175
King, J. & Gill, H. 2015. Q&A on the production of nootkatone (an ingredient of grapefruit flavour). Oxford Biotrans.