SHRED STACK (N-4674 and 5A-699)

Looking for the ultimate SHRED STACK to help move that unwanted body fat as well as tone and increase lean muscle at the same time? We’ve combined N-4674 (GW-501516 Replacement) with 5A-699 MK-2866 Replacement) to achieve the above mentioned!

N-4674 (GW-501516 Replacement) Benefits:

N-4674 is a natural effective cutting agent, an endurance and performance enhancer, it acts as an AMPK (5’ adenosine monophosphate-activated protein kinase) activator. N-4674 is more effective then the product AICAR*.

N-4674 contains a citrus ketone called nootkatone as its phytochemical constitute. Nootkatone is the primary aromatic compound in grapefruit, yet is only found in the low yields of 0.0025% in the fruit. In 2015, a controlled study was done using very large amounts of freshly squeezed grapefruit juice vs prescription fat loss drugs. The grapefruit juice was 300% more effective at burning fat without all the side-effects of synthetic stimulants. But why? Later on in 2015 a study was done on potential anti-cancer chemicals, nootkatone was part of this study. It was found nootkatone was a potent AMPK activator, involved in energy and ATP synthesis, having anti-tumour properties by directly killing lipid (fat) cells.

What N-4674 Does:

It is a potent AMPK activator (same pathway as AICAR)
Stimulates fatty acid oxidation
Induces ketogenisis
Activates energy by binding to AMP and ADP (similar mechanism of action as ATP)
Increases muscle cellular energy and endurance
Increases fat loss and regulates cholesterol synthesis
Induces glucose uptake
N-4674 is more effective then the AICAR*

Specifications:

18.95mg/mL | 3.2mL/day | 60.64mg/day

Serving Size:

1.6mL twice daily | one month supply

Formulation/Ingredients:

N-4674 contains nootkatone (4-α,5-dimethyl-1,2,3,4,4α,5,6,7-octahydro-7-keto-3-isopropenylnaphthalene), in a proprietary SMEDDS blend.

The active compound is isolated from grapefruit.

SMEDDS:

Nootkatone has high lipophilicity and requires SMEDDS to be effective. Our proprietary SMEDDS blend is infused with capric acid, a natural PPAR-γ agonist.

To activate SMEDDS mix the recommended dose by stirring vigorously, shaking, or blending in water, milk, or juice.

Adenosine Stimulation Of N-4674 vs AICAR*

N-4674 (Nootkatone) [1]

Activates AMPK-α
Activates AMPK-β
Inhibits NF-κB (a factor involved in cell survival)

AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) [1]

Mimics AMP
Binds to AMPK-γ subunit
Stimulates mitochondrional apoptosis pathway
Inhibition of mTOR pathway (regulates cell growth)

N-4674 directly activates adenosine whilst AICAR only mimics adenosine. This makes N-4754 superior to the SARM AICAR.

References

Arkwright, R. T., Deshmukh, R., Adapa, N., Stevens, R., Zonder, E., Zhang, Z., Farshi, P., Ahmed, R. S. I., El-Banna, H. A., Chan, T. H. & Dou, Q. P. 2015. Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics. Anticancer Agents In Medicinal Chemistry, 15(5), 657-671. PMID: 25511514

Winder, W. W. & Hardie, D. G. 1999. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. American Journal Of Physiology, 277(1), pp. E1-E10. DOI: 10.1152/ajpendo.1999.277.1.E1

Holmes, B. F., Kurth-Kraczek, E. J. & Winder, W. W. 1999.Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. Journal of Applied Physiology, 87(5), pp. 1990-2010. DOI: 10.1152/jappl.1999.87.5.1990

Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W. & Goodyear, L. J. 1998. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes, 47(8), 1369-1373. DOI: 10.2337/diabetes.47.8.1369

Ojuka, E. O., Jones, T. E., Nolte, L. A., Chen, M., Wamhoff, B. R., Sturek, M. & Holloszy, J. O. 2002. Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+. American Journal Of Physiology, 282(5), pp. E1008-E1013. DOI: 10.1152/ajpendo.00512.2001

Farouk, H., Mahmoud, S. S., El-Sayeh, B. A. & Sharaf, O. A. 2015. Effect of grapefruit juice and sibutramine on body weight loss in obese rats. African Journal of Pharmacy and Pharmacology, 9(8), pp. 265-273. DOI: 10.5897/AJPP2014. 4175

King, J. & Gill, H. 2015. Q&A on the production of nootkatone (an ingredient of grapefruit flavour). Oxford Biotrans.

5A-699 MK-2866 Replacement) Benefits:

5A-699 is an Anabolic Phytosteroid (APS), classified as a brassinosteroid. It is an anabolic compound, a natural effective muscle builder, an endurance and performance enhancer. It has 3% more anabolic activity then the well-known Ostarine (MK-2688)*.

5α-hydroxylaxogenin was discovered in 1996, the Russian chemist Syrov published a peer reviewed journal in 1976 that it had similar anabolic activity to Anavar (Oxandrolone), but without the side effects of hormone imbalances, liver toxicity, or testin positive for steroidal therapy.

What 5A-699 Does:

Increases anabolic activity [1] Increases protein synthesis [1] [5] Increases lipid (fat) and carbohydrate metabolism [1] It has a similar anabolic effect to Anavar (Oxandrolone) [2] It has cAMP phosphodiesterase activity [3] cAMP pathways control anabolism and catabolism [4] No androgenic activity, so no hormonal side effects [2] Safe for women
No PCT needed
Signals PI3K/Akt pathway, responsible for muscle cell growth and division [1] This is the same pathway IGF-1 uses for its muscle building effect
5A-699 has 3% more anabolic activity then the SARM Ostarine (MK-2688)*

Specifications:

77.98mg/mL | 3.6mL/day | 280.7mg/day

Serving Size:

1.8mL twice daily | one month supply

Formulation/Ingredients:

5A-699 contains 5α-hydroxylaxogenin (tetramethylicosahydrospiro[naptho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-2(11aH)-one), in a proprietary SMEDDS blend. The active compound is isolated from Smilax Sieboldii a close relative to asparagus

SMEDDS:

5α-hydroxylaxogenin has medium lipophilicity and requires SMEDDS to be efficient. Our proprietary SMEDDS blend is infused with caprylic acid a natural SARM.

To activate SMEDDS mix the recommended dose by stirring vigorously, shaking, or blending in water, milk, or juice.

Anabolic Activity of 5A-699 vs Ostarine (MK-2688)

5A-699 (5α-hydroxylaxogenin)

Ostarine (MK-2688)

* Results according to Molinspiration molecular structure nuclear receptor bioactivity.

References

Fasciola, A. A. 2013. Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals. Google Patents. PUB US20140274978A1
Syrov, V. N. & Kurmukov, A. G. 1976. Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins. Farmakol Toksikol, 39(5), 631-635. PMID 1028596
Tian, L. W., Zhang, Z., Long, H. L. & Zhang, Y. J. 2017. Steroidal Saponins from the Genus Smilax and Their Biological Activities. Natural Products and Bioprospecting, 7(4), pp. 283–298. DOI 10.1007/s13659-017-0139-5
Raker, V. K., Becker, C. & Steinbrink, K. 2016. The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases. Frontiers in Immunology, 7(123). DOI 10.3389/fimmu.2016.00123
Rangel, J. A. O. 2006. Hepato phyto-nutraceutical synergistic composition. Google Patents. PUB US7625587B2